|
KMID : 0617819950050010299
|
|
Journal of Wonkwang Oriental Medicine
1995 Volume.5 No. 1 p.299 ~ p.316
|
|
|
Effects of Dansamyeum on the Cardiovascular System in the Experimental Animals
|
|
申善澔/Shin, Sun-Ho
李基商/文病淳/Lee, Gi-Sang/Moon, Byoung-Soon
|
|
|
Abstract
|
|
|
The present experiment was desinged to investigate the effects of Dansamyeum water extracts on the Cardivascular System in the Experimental Animals. Thus, the changes of blood pressure and heart rate were measured after oral administration.
Measurments of Mortality rate were observed for measuring the effects of Dansamyeum water extract. Dansamyeum water extracts against pulmonary thromboembolism induced by collagen the mixture 90.1㎖/10g, 2㎖/㎏ B.W) plus serotonin(5㎎/㎏ B.W) in mouse.
The effect of Dansamyeum water extract was examined by observing the change of collagen-induced platelet aggregation coagulation activity, ex vivo and in vitro fibrinolytic activity of euglobulin fraction in rats.
The results were summarized as followings.
1. Dansamyeum dropped the blood pressure in spontaneous hypertensive rat.
2. The drug increased the auricular blood flow in rabbit.
3. The drug relaxed the artery contraction by pretreated norepinephrine in rat.
4. The drug inhibited the death rate of mouse which were led to thromboembolism by serotonin and collagen.
5. The drug inhibited the platelet aggregation in rat.
6. The drug prolonged the prothrombin time and activated partial thromboplastin time on the test of plasma coagulation factor activity in rat, but was not valuable.
7. The drug increased the antithrombin activity in rat and the fibrinogen lyses time was reduced and lyses area was increased.
8. Dansamyeum reduced fibrinogen lyses time of rat in vitro assay.
According to the above mentioned results, Dansamyium increased the blood flow and dropped the blood pressure by the dilation of blood vessel. And the drug presented the antithrombin acivity, inhibited the platelet aggregation.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|